HSD11B2 Antibody | XW-8141

HSD11B2 Antibody | XW-8141 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human, Rat, Chicken

Homology: N/A

Immunogen: 181-405

Research Area: Other

Tested Application: WB

Application: Corticosteroid 11-β-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-β-dehydrogenase, isozyme 2 by Western Blot.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 44.1 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Immunoaffinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: HSD11B2 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: HSD11K, Corticosteroid 11-beta-dehydrogenase isozyme 2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, AME, AME1, HSD2, HSD11K, SDR9C3, Corticosteroid 11bdehydrogenase, isozyme 2, 11-beta-HSD2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.