LBD
HSD17B7 Antibody (N-term) [APR07821G]
- SKU:
- LBD-APR07821G
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Description
HSD17B7 Antibody (N-term) [APR07821G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HSD17B7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human HSD17B7.
Cellular Localisation: Endoplasmic reticulum membrane; Single-pass membrane protein
Molecular Weight: 38206
Clone: Polyclonal
Gene Name: HSD17B7
Gene ID: 51478
Function: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030) . Catalyzes the NADP (H) -dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289) . Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b, 17b- diol (PubMed:12574203, PubMed:12732193, PubMed:19772289) . Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193) . Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3- ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030) .
Summary: Tissue Location: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea Weakly expressed in all other tissues tested
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: 3-keto-steroid reductase, 17-beta-hydroxysteroid dehydrogenase 7, 17-beta-HSD 7, Estradiol 17-beta-dehydrogenase 7, HSD17B7