Human CD19 protein, Fc tag (Animal-Free) | PRP2030

Human CD19 protein, Fc tag (Animal-Free) | PRP2030 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cytokines

Product Type: Cytokines (Animal-Free)

Sequence: Amino acid sequence derived from human CD19 protein (P15391-1, Pro20-Lys291) was expressed with the Fc region of human IgG1 at the C-terminus.

Activity: N/A

protein Lenght: The recombinant human CD19 protein consists of 509 amino acids and predicts a molecular mass of 56.9 kD. The apparent molecular mass of the human CD19 is approximately 70-90 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Preparation: HEK 293 Cells

Purity: >90% as determined by SDS-PAGE

Formulation: 0.22 µm filtered protein solution is in PBS, pH 7.4.

Kit Component: N/A

Features & Benefits : Endotoxin: <1 EU per μg of the protein as determined by the LAL method.

Molecular Weight: 56.9 kDa

Usage Note: Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized human CD19 protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.

Storage Conditions: Lyophilized Human CD19 protein, Fc tag (Animal-Free) should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.109% HSA or BSA) . Please prevent freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature.

Background: CD19 is a B-lineage-specific transmembrane glycoprotein, the expression of which is maintained on more than 95% B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs) . In normal cells, it is the most ubiquitously expressed protein in the B lymphocyte lineage. CD19 expression is induced at the point of B lineage commitment during the differentiation of the hematopoietic stem cell, and its expression continues through preB and mature B cell differentiation until it is finally down-regulated during terminal differentiation into plasma cells. CD19 expression is maintained in B-lineage cells that have undergone neoplastic transformation, and therefore CD19 is useful in diagnosis of leukemias and lymphomas using monoclonal antibodies (mAbs) and flow cytometry.

Alternative Names: CD19 Molecule;B-Lymphocyte Surface Antigen B4;T-Cell Surface Antigen Leu-12;Differentiation Antigen CD19;B-Lymphocyte Antigen CD19;CD19 Antigen;CVID3;CD19;B4

Search Names: CD19 Molecule;B-Lymphocyte Surface Antigen B4;T-Cell Surface Antigen Leu-12;Differentiation Antigen CD19;B-Lymphocyte Antigen CD19;CD19 Antigen;CVID3;CD19;B4

Tag: CD19