Human CellExp™ B7-H6, human recombinant | P1013

B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

P1013 | Human CellExp B7-H6 human recombinant DataSheet

Biomolecule/Target: NCR3LG1

Synonyms: Natural cytotoxicity triggering receptor 3 ligand 1

Alternates names: Cytotoxic lymphocyte maturation factor 40 kDa subunit Short name=CLMF p40 IL-12 subunit p40 NK cell stimulatory factor chain 2

Taglines: Triggers NCR3-dependent natural killer cell activation.

NCBI Gene ID #: 3593

NCBI Gene Symbol: IL12

Gene Source: Human

Accession #: P29460

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 5 EU/mg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 40.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2m-filtered solution in PBS.

Reconstitution Instructions: Reconstitute in 1X PBS, pH 7.2 to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A