Human CellExp™ BMP-4, Human Recombinant | 6445

BMP4 belongs to the transforming growth factor-beta (TGF) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-4 plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

6445 | Human CellExp BMP-4 Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant BMP-4

Alternates names: Proepithelin; PEPI; PC Cell-derived Growth Factor

Taglines: A protein involved in bone and cartilage development

NCBI Gene ID #: 10116

NCBI Gene Symbol: GRN

Gene Source: Human

Accession #: P23785

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 g of protein

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~65.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a PBS solution.

Reconstitution Instructions: Reconstitute in dH2O before use.

Amino acid sequence: Signal peptide and rat Progranulin (aa 1-602) fused at the C-terminus to a FLAG®-tag.