Human CellExp™ CD159a / KLRC1 (Active), Human Recombinant | P1730

The Killer Cell Lectin Like Receptor C1 (KLRC1, also known as CD159a) is a member of the NKG2 family, a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. KLRC1 forms a complex with KLRD1 (CD94), and is implicated in the reccognition of the MHC class I HLA-E molecules in NK cells. KLRC1 enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self, as well as monitoring the activation and effector functions of NK cells. In viral infections and some tumor microenvironments, KLRC1 is a key target to downregulate NK cell cytotoxicity and allow tumor progression and viral escape from immune surveillance.

P1730 | Human CellExp™ CD159a / KLRC1 (Active), Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2

Alternates names: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2

Taglines: An immune inhibitory receptor involved in self-nonself discrimination

NCBI Gene ID #: 3821

NCBI Gene Symbol:

Gene Source: Human

Accession #: P26715

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE: > 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: < 1.0 EU per ug as determined by the LAL method

Activity (Specifications/test method): Immobilized Human KLRC1-His at 10 ug/ml (100 ul/well) can bind Biotinylated Human CD94-His. The ED50 of Human KLRC1-His is 18 ug/mL.

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 16.5 kDa calculated; 25-40 kDa observed

Concentration:

Appearance: Lyophilized protein

Physical form description:

Reconstitution Instructions:

Amino acid sequence: Arg 100 to Leu 233 with N-terminal 8xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans