Human CellExp™ CD19, Fc Tag, Rhesus macaque recombinant | P1329

B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.

P1329 | Human CellExp CD19 Fc Tag Rhesus macaque recombinant DataSheet

Biomolecule/Target: CD19

Synonyms: CD19, B4, CVID3, MGC12803

Alternates names: Trefoil Factor 2, Spasmolytic polypeptide (SP), Spasmolysin

Taglines: B-lymphocyte antigen CD19

NCBI Gene ID #: 7032

NCBI Gene Symbol: TFF2

Gene Source: Rhesus macaque

Accession #: Q03404

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/g

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 µg/ml.

Results: 1.0-10.0 µg/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 12.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 g/l. The solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A