Human CellExp™ CD27 Ligand/ CD70, Fc Tag, Mouse Recombinant | P1367

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.

P1367 | Human CellExp CD27 Ligand/ CD70 Fc Tag Mouse Recombinant DataSheet

Biomolecule/Target: CD70

Synonyms: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L

Alternates names: Growth/Differentiation Factor-3

Taglines: Cytokine that binds to CD27 and plays role in T-cell activation.

NCBI Gene ID #: 9573

NCBI Gene Symbol: GDF3

Gene Source: Mouse

Accession #: Q9NR23

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: >95%

Assay #2: HPLC

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA

Biological activity: Test in process

Results: N/A

Binding Capacity: Immobilized Mouse CD27, Mouse IgG2a Fc Tag, at 2 g/mL (100 L/well) can bind Mouse CD27 Ligand (active trimer) with a linear range of 0.1-4 ng/mL

Unit Definition: N/A

Molecular Weight: 13 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A