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Human CellExp™ CD33/SIGLEC-3 | 7370
- SKU:
- 26-7370-GEN
- Availability:
- Usually shipped in 5 working days
Description
Myeloid cell surface antigen CD33 also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 Domain (s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
7370 | Human CellExp CD33 / SIGLEC-3 human recombinant DataSheet
Biomolecule/Target: CD33/SIGLEC-3
Synonyms: CD33, SIGLEC3, gp67
Alternates names: Apolipoprotein E2, apolipoprotein, apolipoproteins
Taglines: Human recombinant with 6xHis tag
NCBI Gene ID #: 348
NCBI Gene Symbol: ApoE
Gene Source: Human
Accession #: NM_000041
Recombinant: Yes
Source: HEK293 cells (Asp 18-His 259 of human protein)
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: Test in process
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 34.3 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in dHO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A