Human CellExp™ COMP/TSP5, human recombinant | 7452

Cartilage oligomeric matrix protein (COMP) also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contain 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

7452 | Human CellExp COMP/TSP5 human recombinant DataSheet

Biomolecule/Target: COMP/TSP5

Synonyms: COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5.

Alternates names: Thrombospondin-1, THBS1, TSP, TSP1, THBS, THBS-1

Taglines: A marker of cartilage turnover

NCBI Gene ID #: 7057

NCBI Gene Symbol: TSP1

Gene Source: Human

Accession #: P07996

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 180 kDa in reducing Gel

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM NaCl, pH 7.5. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute with water at the concentration 0.1 mg/ml.

Amino acid sequence: N/A