Human CellExp™ CTLA-4/CD152, mouse recombinant | P1081

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

P1081 | Human CellExp CTLA-4/CD152 mouse recombinant DataSheet

Biomolecule/Target: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12

Alternates names:

Taglines: A protein receptor that downregulates the immune system.

NCBI Gene ID #: 4100

NCBI Gene Symbol: MAGEA1

Gene Source: Mouse

Accession #: P43355

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/g

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Mouse B7-1 and B7-2, Fc Tag at 0.2 g/mL (100 L/well) can bind Mouse CTLA-4, mouse IgG2a Fc tag with a linear range of 0.1-3 ng/mL and 0.4-3 ng/mL respectively.

Unit Definition: N/A

Molecular Weight: 38 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: N/A