Human CellExp™ GFR alpha-like, Human Recombinant | P1386

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor -like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

P1386 | Human CellExp GFR alpha-like Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: GFR alpha like, GFR alpha-like, GFRAL, GRAL

Alternates names: Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1b, MGC96956

Taglines: Neuronal brainstem receptor mediating the anorectic funtions of GDF15

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: FALSE

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per g by the LAL method

Activity (Specifications/test method): N/A

Biological activity: ’s Interferon 1b is fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 10 IU/ mg.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 18.5 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A