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Human CellExp™ GFRA2 /GDNFRB, human recombinant | 7470
- SKU:
- 26-7470-GEN
- Availability:
- Usually shipped in 5 working days
Description
GDNF family receptor alpha-2 (GFRA2) also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFR-1, GFR-2 and GFR-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
7470 | Human CellExp GFRA2 /GDNFRB human recombinant DataSheet
Biomolecule/Target: GFRA2 /GDNFRB
Synonyms: GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2.
Alternates names: USP5; Ubiquitin-specific protease 5
Taglines: Involved in the initiation of the RET signaling pathway
NCBI Gene ID #: 8078
NCBI Gene Symbol: UBP5
Gene Source: Human
Accession #: P45974
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 97.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: N/A