Human CellExp™ HER3 / ErbB3 Extracellular Domain (ED), Human Recombinant | 7400

ErbB3, also called human epidermal growth factor receptor 3 (HER3), is a type I membrane glycoprotein and a member of the ErbB family. ErbB family members serve as receptors for the epidermal growth factors (EGF). ErbB3 is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. ErbB3 is the only member with a defective kinase domain among ErbB family members. However, ErbB3 can form heterodimers with ErbB2 to complement a high affinity receptor complex. ErbB3 has been shown to bind the ligands heregulin and NRG-2. The lethal congenital contracture syndrome 2 (LCCS2) disease is caused by mutations affecting ErbB3. ErbB3 null mouse embryos show severely underdeveloped atrioventricular valves, leading to death at embryonic day 13.5.

7400 | Human CellExp HER3 / ErbB3 Extracellular Domain ED Human Recombinant DataSheet

Biomolecule/Target: ErbB3

Synonyms: ERBB3, ErbB-3, HER3, HER-3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, Receptor tyrosine-protein kinase erbB-3

Alternates names: Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B

Taglines: Involved in pathways leading to cell proliferation or differentiation.

NCBI Gene ID #: 10637

NCBI Gene Symbol: LEFTY1

Gene Source: Human

Accession #: O75610

Recombinant: Yes

Source: Human 293 cells

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse Chondrogenic cell line).

Results: Typically 10 to 40 ng/mL ED50.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 38 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered PBS (pH 7.4)

Reconstitution Instructions: Reconstitute in sterile water.

Amino acid sequence: N/A