Human CellExp™ ICOS / CD278, Fc Tag, Human recombinant | P1378

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

P1378 | Human CellExp ICOS / CD278 Fc Tag Human recombinant DataSheet

Biomolecule/Target: ICOS / CD278

Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator

Alternates names: BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, CD_antigen=CD292

Taglines: Inducible T-cell costimulator

NCBI Gene ID #: 657

NCBI Gene Symbol: BMPR1A

Gene Source: Human

Accession #: P36894

Recombinant: TRUE

Source: Insect cells (Baculovirus)

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per g by the LAL method.

Activity (Specifications/test method): Immobilized Human B7-H2, His Tag at 1 g/mL (100 L/well) can bind Human ICOS, Fc Tag with a linear range of 0.4-6 ng/mL

Biological activity: Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant human BMP-2.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 23.0 kDa

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.

Amino acid sequence: N/A