Human CellExp™ ROR1, Fc Tag, Human Recombinant | P1750

Human CellExp™ ROR1, Fc Tag, Human Recombinant | P1750

Description: Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Biomolecule/Target:

Synonyms: Receptor Tyrosine Kinase Like Orphan Receptor 1; NTRKR1; Neurotophic Tyrosine Kinase, Receptor-Related 1

Alternates names: Receptor Tyrosine Kinase Like Orphan Receptor 1; NTRKR1; Neurotophic Tyrosine Kinase, Receptor-Related 1

Taglines: Receptor for Wnt ligand WNT5A

NCBI Gene ID #: 4919

NCBI Gene Symbol: Human

Accession #: Q01973

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE: > 90% as determined by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: ~69 kDa (observed due to glycosylation)

Concentration:

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions:

Amino acid sequence: Gln 30 to Glu 403 with C-terminal Fc of human IgG1

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans