Human CellExp™ ROR1, Fc Tag, Human Recombinant | P1248

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

P1248 | Human CellExp ROR1 Fc Tag Human Recombinant DataSheet

Biomolecule/Target: ROR1

Synonyms: ROR1, NTRKR1

Alternates names: Interleukin 31, IL31

Taglines: Receptor for wnt ligand WNT5A

NCBI Gene ID #: 76399

NCBI Gene Symbol: IL31

Gene Source: Mouse

Accession #: Q6EAL8

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: A standard activity has not yet been determined.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 15.7 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile HO at a concentration of 0.1mg/ml. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage. Reconstituted IL-31 should be stored in working aliquots at -20°C.

Amino acid sequence: MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C