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Human CellExp™ ICOS / CD278, Mouse Recombinant | P1469
- SKU:
- 26-P1469-GEN
- Availability:
- Usually shipped in 5 working days
Description
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
P1469 | Human CellExp™ ICOS / CD278, Mouse Recombinant DataSheet
Biomolecule/Target :
Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator
Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator
Taglines: Inducible T-cell costimulator
NCBI Gene ID #: 54167
NCBI Gene Symbol: Icos
Gene Source: Mouse
Accession #: Q9WVS0-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity: Immobilized Human B7-H2 at 1 ug/mL (100 uL/well) can bind Mouse ICOS with a linear range of 0.01-0.2ng/mL
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: Glu 21 - Leu 144
Handling: Centrifuge the vial prior to opening.
Usage:
Additional Information
Storage Temperature: |
-20°C |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |