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Human CellExp™ IL-1 RII /CD121b, human recombinant | 7392
- SKU:
- 26-7392-GEN
- Availability:
- Usually shipped in 5 working days
Description
Interleukin-1 receptor type 2 (IL1R2) also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
7392 | Human CellExp IL-1 RII /CD121b human recombinant DataSheet
Biomolecule/Target: IL-1 RII /CD121b
Synonyms: CD121b, IL1RB, IL1R2, CDw121b
Alternates names: Thymic Stromal Lymphopoietin
Taglines: Serves as a decoy receptor by competitive binding to IL1B
NCBI Gene ID #: 85480
NCBI Gene Symbol: TSLP
Gene Source: Human
Accession #: Q969D9
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: The ED determined by the ability to induce proliferation of human Interleukin-7 receptor & human TSLP Receptor co-transfected with mouse BaF3 cells was found to be less than 0.3 ng/ml.
Results: <0.3 ng/ml.
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 15.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile dHO to a concentration of 0.1 -1 mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A