Human CellExp™ IL-17A, Human Recombinant | 6468

Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.

6468 | Human CellExp IL-17A Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant IL-17A

Alternates names: Acrp-30, GBP-28, Apm-1, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein

Taglines: A proinflammatory cytokine produced by activated T cells

NCBI Gene ID #: 9370

NCBI Gene Symbol: ADIPOQ

Gene Source: Human

Accession #: NP_004788

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 g of protein

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 30 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl.

Reconstitution Instructions: Recontitute in water containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/ml. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A