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Human CellExp™ IL-4 R, Human Recombinant | 7101

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SKU:
26-7101-GEN
Availability:
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£938.00 - £2,938.00

Description

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (c). The type I receptor contains in addition to the c an IL-4R subunit, whereas the type II receptor contains the IL-13R. The secreted extracellular domain of IL-4R, called sIL-4R, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4R is a 209 amino acid protein which corresponds to the entire extracellular domain of IL- 4R.

7101 | Human CellExp IL-4 R Human Recombinant DataSheet

Biomolecule/Target: IL-4 R

Synonyms: soluble IL-4 receptor alpha, CD124

Alternates names: PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik.

Taglines: A receptor for both interleukin 4 and interleukin 13

NCBI Gene ID #: 10135

NCBI Gene Symbol: NAMPT

Gene Source: Human

Accession #: P43490

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): Determined by its ability to inhibit the IL-4-dependent proliferation of human TF-1 cells. The expected ED50 is 5.0 ng/ml (in the presence of 0.5 ng/ml of hIL-4), corresponding to a specific activity of 2 x 105 units/mg.

Biological activity:

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 55.0 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.

Reconstitution Instructions: Reconstitute in PBS to the concentration of 0.1-1 mg/ml.

Amino acid sequence: N/A

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Additional Information

Storage:
-20°C
Shipping:
Gel Pack
Shelf Life:
12 months
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