Human CellExp™ Insulin R / CD220, Human Recombinant | P1377

Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

P1377 | Human CellExp Insulin R / CD220 Human Recombinant DataSheet

Biomolecule/Target: Insulin R / CD220

Synonyms: INSR, Insulin receptor, IR, CD220

Alternates names: Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF

Taglines: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

NCBI Gene ID #: 297508

NCBI Gene Symbol: NAMPT

Gene Source: Rat

Accession #: Q80Z29

Recombinant: TRUE

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per g by the LAL method.

Activity (Specifications/test method):

Biological activity: Amino acids 1 to 491 (per UniProt Q80Z29)

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 53.0 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in PBS to the concentration of 0.1-1 mg/ml.

Amino acid sequence: Amino acids 1 to 491 (per UniProt Q80Z29)