Human CellExp KLF4-TAT, Human Recombinant | P1011

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

P1011 | Human CellExp KLF4-TAT Human Recombinant DataSheet

Biomolecule/Target: KLF4-TAT

Synonyms: Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, EZF, GKLF

Alternates names: VGR, VGR1, BMP-6, VG-1-related protein

Taglines: A transcription factor that act both as an activator and as a repressor.

NCBI Gene ID #: 654

NCBI Gene Symbol: BMP6

Gene Source: Human

Accession #: P22004

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 90%

Assay #2: HPLC

Endotoxin Level: < 1 EU/g

Activity (Specifications/test method): N/A

Biological activity: ’s recombinant human BMP-6 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.

Results: 2-12 µg/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: monomer (15 kDa), dimer (30 kDa)

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A