Human CellExp™ LYVE-1, mouse recombinant | P1017

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.

P1017 | Human CellExp LYVE-1 mouse recombinant DataSheet

Biomolecule/Target: Lyve1

Synonyms: Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1, Xlkd1, Lyve-1, Crsbp-1

Alternates names: Lipopolysaccharide-binding protein, LBP, LBP human recombinant protein, LBP human, human LBP

Taglines: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane.

NCBI Gene ID #: 3929

NCBI Gene Symbol: LBP

Gene Source: Human

Accession #: P18428

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGEs: 90-95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 5 EU/mg

Activity (Specifications/test method): N/A

Biological activity: Up to 0.2 µg/ ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14+CHO transfectants (FACS).

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 58.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2m-filtered solution in PBS.

Reconstitution Instructions: Reconstitute in 40 µl of ultra-pure distilled HO. This solution can then be diluted into other aqueous buffers and stored at –20°C or –70°C for future use.

Amino acid sequence: N/A