Human CellExp™ Noggin, Human Recombinant | 6474

Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF- family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

6474 | Human CellExp Noggin Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant Noggin

Alternates names: SUMO3; SMT3A; SMT3H1; SUMO-3, SMT3 homolog 1, SUMO-2, Ubiquitin-like protein SMT3B

Taglines: An inhibitor of TGF- signal transduction

NCBI Gene ID #:

NCBI Gene Symbol: SUMO3

Gene Source: Human

Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 g of protein

Activity (Specifications/test method): N/A

Biological activity: Typical in vitro concentrations for conjgate formation is 10-50 µM depending on conditions.

Results: 10-50 µM

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 11.6 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in PBS.

Reconstitution Instructions: N/A

Amino acid sequence: N/A