Human CellExp™ PD-L2 / B7-DC, mouse recombinant | P1087

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

P1087 | Human CellExp PD-L2 / B7-DC mouse recombinant DataSheet

Biomolecule/Target: PD-L2

Synonyms: PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2

Alternates names: EPG, Epigen, PRO9904, ALGV3072, FLJ75542, EPGN, Epithelial mitogen,

Taglines: A protein involved in the costimulatory signal essential for T-cell proliferation.

NCBI Gene ID #: 255324

NCBI Gene Symbol: EPGN

Gene Source: Human

Accession #: Q6UW88

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.1 EU/g

Activity (Specifications/test method): N/A

Biological activity: Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED for this effect is 150-300 ng/ml.

Results: 150-300 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 7.9 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Amino acid sequence: N/A