Human CellExp™ SCARB2 /CD36L2 /LIMP2, human recombinant | 7509

Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. It may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMP2 enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMP2 also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.

7509 | Human CellExp SCARB2 /CD36L2 /LIMP2 human recombinant DataSheet

Biomolecule/Target: SCARB2 /CD36L2 /LIMP2

Synonyms: SCARB2, CD36L2, LIMP2, LIMPII, LGP85, CD36, AMRF, EPM4, HLGP85, SR-BII

Alternates names: PRL-R, hPRLrI, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R

Taglines: 95% pure, active, human cell expressed, human recombinant SCARB2 /CD36L2 /LIMP2 - a lysosomal receptor for glucosylceramidase (GBA) targeting

NCBI Gene ID #: 5618

NCBI Gene Symbol: PRLR

Gene Source: Human

Accession #: P16471

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Determined by the dose-dependent inhibition of Prolactin stimulated proliferation of Nb2 cells and by high affinity binding of ovine Prolactin and other lactogenic hormones in 1:1 molar ratio.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 23.97 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM glycine, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in sterile dHO to a concentration of 0.1 -1 mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A