Human CellExp™ Siglec-15, Human Recombinant | P1343

Siglec-15 is a transmembrane glycoprotein of the siglecs family that participates in the immune regulatory systems through the recognition of their glycan ligands. Siglecs, short for sialic acid-binding immunoglobulin (Ig)-like lectins, are primarily expressed on the surface of immune cells and differentially control innate and adaptive immune responses. Mature human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD, Phe20 - Thr263) with two Ig-like domains, a 21 aa transmembrane segment (264-284), and a 44 aa cytoplasmic domain (285-328). Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemia, and ability to modulate receptor signaling. Because Siglec-15 is critical for proper development and function of osteoclasts, anti-Siglec-15 antibodies have therapeutic potential for treatment of osteoporosis.

P1343 | Human CellExp Siglec-15 Human Recombinant DataSheet

Biomolecule/Target: Siglec-15

Synonyms: Sialic acid-binding immunoglobulin (Ig)-like lectin 15, CD33 antigen-like 3, CD33 molecule-like 3, CD33L3

Alternates names: mCherry

Taglines: Transmembrane glycoprotein that controls innate and adoptive immune response.

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source:

Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 28.8 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered PBS (pH 7.4) with 5% trehalose

Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml

Amino acid sequence: N/A