Human CellExp™ TLR-3, Human Recombinant | 7220

TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-¬B pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.4 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

7220 | Human CellExp TLR-3 Human Recombinant DataSheet

Biomolecule/Target: TLR3

Synonyms: Toll-like receptor 3; CD283 antigen

Alternates names: E-GFP, Enhanced Green Fluorescent Protein

Taglines: Promotes the NF-kB pathway to initiate innate and adaptive immune responses

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source:

Accession #: P42212

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs:

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 32.7 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 20 mM Sodium Phosphate, pH 7.5.

Reconstitution Instructions: Reconstitute with PBS to 1 mg/ml

Amino acid sequence: N/A