Human CellExp™ TNFR1 / CD120a / TNFRSF1A, human recombinant | 7382

Tumor necrosis factor receptor 1 (TNF-R1) also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial Hibernian fever (FHF).

7382 | Human CellExp TNFR1 / CD120a / TNFRSF1A human recombinant DataSheet

Biomolecule/Target: TNFR1 / CD120a / TNFRSF1A

Synonyms: TNFR1, CD120a, TNFRSF1A, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR55, TNFR60, p55, p60.

Alternates names: RFP, Red Fluorescent Protein, R-PE, R-Phycoerythrin

Taglines: Contributes to the induction of non - cytocidal TNF effects

NCBI Gene ID #: N/A

NCBI Gene Symbol: R-PE

Gene Source: Red algae

Accession #: N/A

Recombinant: Yes

Source: Febico’s proprietary red algae

Purity by SDS-PAGEs: A566/A280 5.5

Assay: Absorbance

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 240 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Before use, centrifuge the R-PE suspension at 10,000g for 10 min at 4C. Discard the supernatant and resuspend the pellet (R-PE) into the desired buffer. R-PE is stored in a salt solution and it must be extensively dialyzed (Can use ’s Dialyzer tubes) or desalted in columns ( Cat # 6564-25) prior to use, to remove any remaining ammonium sulphate.

Amino acid sequence: N/A