Human CellExp™ TNFRSF10A / TRAIL R1, human recombinant | P1141

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

P1141 | Human CellExp TNFRSF10A / TRAIL R1 human recombinant DataSheet

Biomolecule/Target: TNFRSF10A

Synonyms: TNFRSF10A, TRAIL-R1, CD261, APO2, DR4

Alternates names: KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin

Taglines: Receptor for the cytotoxic ligand TNFSF10/TRAIL

NCBI Gene ID #: N/A

NCBI Gene Symbol: KLH

Gene Source: Megathura crenulata

Accession #: N/A

Recombinant: Yes

Source: Megathura crenulata, Giant keyhole limpet

Purity by SDS-PAGEs: 95%

Assay: MPLC-SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 350 and 390 kDa (Two main characteristic bands co-migrating with ferritin)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Resuspend in sterile water to a 1 mg/ml concentration

Amino acid sequence: N/A