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Human CellExp™ TNFRSF10A / TRAIL R1, human recombinant | P1141
- SKU:
- 26-P1141-GEN
- Availability:
- Usually shipped in 5 working days
Description
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
P1141 | Human CellExp TNFRSF10A / TRAIL R1 human recombinant DataSheet
Biomolecule/Target: TNFRSF10A
Synonyms: TNFRSF10A, TRAIL-R1, CD261, APO2, DR4
Alternates names: KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Taglines: Receptor for the cytotoxic ligand TNFSF10/TRAIL
NCBI Gene ID #: N/A
NCBI Gene Symbol: KLH
Gene Source: Megathura crenulata
Accession #: N/A
Recombinant: Yes
Source: Megathura crenulata, Giant keyhole limpet
Purity by SDS-PAGEs: 95%
Assay: MPLC-SEC
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 350 and 390 kDa (Two main characteristic bands co-migrating with ferritin)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Resuspend in sterile water to a 1 mg/ml concentration
Amino acid sequence: N/A