Human CellExp™ TNFSF11 / RANKL / CD254, Human Recombinant | P1206

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes.

P1206 | Human CellExp TNFSF11 / RANKL / CD254 Human Recombinant DataSheet

Biomolecule/Target: TNFSF11

Synonyms: RANKL, CD254, TRANCE, OPGL, ODF

Alternates names: Angiotensinogenase, REN.

Taglines: Tumor necrosis factor ligand superfamily member 11 stimulates osteoclast formation.

NCBI Gene ID #: 5972

NCBI Gene Symbol: REN

Gene Source: Human

Accession #: P00797

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): The specific activity is > 20 U/mg. The specific activity of active Renin was assayed using ’s Renin Activity Fluorometric Assay Kit (Catalog # K800).

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Human TNFRSF11A at 5 g/mL (100 L/well) can bind Human TNFSF11, His Tag with a linear range of 0.2-6 ng/mL

Unit Definition: N/A

Molecular Weight: 43 kDa (C terminal 8×His tag)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: Leu 67 – Arg 406