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Human CellExp™ TNFSF11 / RANKL / CD254, Human Recombinant | P1206
- SKU:
- 26-P1206-GEN
- Availability:
- Usually shipped in 5 working days
Description
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes.
P1206 | Human CellExp TNFSF11 / RANKL / CD254 Human Recombinant DataSheet
Biomolecule/Target: TNFSF11
Synonyms: RANKL, CD254, TRANCE, OPGL, ODF
Alternates names: Angiotensinogenase, REN.
Taglines: Tumor necrosis factor ligand superfamily member 11 stimulates osteoclast formation.
NCBI Gene ID #: 5972
NCBI Gene Symbol: REN
Gene Source: Human
Accession #: P00797
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): The specific activity is > 20 U/mg. The specific activity of active Renin was assayed using s Renin Activity Fluorometric Assay Kit (Catalog # K800).
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized Human TNFRSF11A at 5 g/mL (100 L/well) can bind Human TNFSF11, His Tag with a linear range of 0.2-6 ng/mL
Unit Definition: N/A
Molecular Weight: 43 kDa (C terminal 8×His tag)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: Leu 67 Arg 406