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Human CellExp™ TRAIL R2 / TNFRSF10B, Mouse recombinant | P1421
- SKU:
- 26-P1421-GEN
- Availability:
- Usually shipped in 5 working days
Description
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
P1421 | Human CellExp™ TRAIL R2 / TNFRSF10B, Mouse recombinant DataSheet
Biomolecule/Target :
Synonyms: TNFRSF10B, TRAILR2, TRAIL-R2, CD262,DR5, KILLER, TRICK2, ZTNFR9, TRICKB
Alternates names: TNFRSF10B, TRAILR2, TRAIL-R2, CD262,DR5, KILLER, TRICK2, ZTNFR9, TRICKB
Taglines: Promotes the activation of NF-kappa-B
NCBI Gene ID #: 21933
NCBI Gene Symbol: Tnfrsf10b
Gene Source: Mouse
Accession #: Q9QZM4-1
Recombinant: True
Source: HEK 293 Cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.1 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Asn 53 - Lys 180
Handling: Centrifuge the vial prior to opening.
Usage:
Additional Information
Storage Temperature: |
-20ºC |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |