Human CellExp™ VEGF-D, Human recombinant | P1133

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

P1133 | Human CellExp VEGF-D Human recombinant DataSheet

Biomolecule/Target: VEGFD

Synonyms: FIGF, VEGFD

Alternates names: FIGF, VEGFD

Taglines: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth

NCBI Gene ID #: 3578

NCBI Gene Symbol: IL9

Gene Source: Human

Accession #: P15248

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Human VEGF R3, Fc Tag at 5g/mL (100 l/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 g/ml.

Results: N/A

Binding Capacity: Immobilized Human VEGF R3, Fc Tag at 5g/mL (100 l/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 g/ml.

Unit Definition: N/A

Molecular Weight: 13 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Amino acid sequence: N/A