Human CellExp™ VEGF R1 /Flt-1, Rhesus macaque Recombinant | P1394

Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.

P1394 | Human CellExp VEGF R1 /Flt-1 Rhesus macaque Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: FLT, VEGFR1, FLT1

Alternates names: Peptidylprolyl isomerase H, CYPH, CYP20, SnuCyp-20, PPIase H, Rotamase H

Taglines: Plays an essential role in the development of embryonic vasculature

NCBI Gene ID #: 10465

NCBI Gene Symbol: PPIH

Gene Source: Human

Accession #: O43447

Recombinant: TRUE

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 0.1 EU per g by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 220 nmoles/min/mg

Results:

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.2 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: N/A

Amino acid sequence: MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM