Human CellExp™ VEGF R3, Fc Tag, human recombinant | P1148

Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

P1148 | Human CellExp VEGF R3 Fc Tag human recombinant DataSheet

Biomolecule/Target: FLT4

Synonyms: Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL

Alternates names: Peptidylprolyl isomerase E isoform 1, PPIE, CYP-33, Cyclophilin E, PPIase E, Rotamase E

Taglines: Cell-surface receptor for VEGFC and VEGFD

NCBI Gene ID #: 10450

NCBI Gene Symbol: PPIE

Gene Source: Human

Accession #: Q9UNP9

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 210 nmoles/min/mg

Results:

Binding Capacity: Immobilized Human VEGF-C, His Tag at 5g/mL (100 L/well) can bind Human VEGF R3, Fc Tag with a linear range of 0.6-10 ng/mL. Immobilized Human VEGF R3, Fc Tag at 5g/mL (100 L/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 g/mL.

Unit Definition: N/A

Molecular Weight: 37.5 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMATT KRVLYVGGLA EEVDDKVLHA AFIPFGDITD IQIPLDYETE KHRGFAFVEF ELAEDAAAAI DNMNESELFG RTIRVNLAKP MRIKEGSSRP VWSDDDWLKK FSGKTLEENK EEEGSEPPKA ETQEGEPIAK KARSNPQVYM DIKIGNKPAG RIQMLLRSDV VPMTAENFRC LCTHEKGFGF KGSSFHRIIP QFMCQGGDFT NHNGTGGKSI YGKKFDDENF ILKHTGPGLL SMANSGPNTN GSQFFLTCDK TDWLDGKHVV FGEVTEGLDV LRQIEAQGSK DGKPKQKVII ADCGEYV