Human Chorionic Gonadotropin, β Subunit | P1714

Chorionic gonadotropin (CG) is produced by the trophoblastic cells of the placenta and stimulates the ovaries to release steroids essential for maintaining pregnancy. The four human glycoprotein hormones (CG, luteinizing hormone, follicle stimulating hormone, and thyroid stimulating hormone) are dimers consisting of alpha and beta subunits. The alpha subunits of these hormones are identical, while they each have unique beta subunits that allow the hormones to bind specific receptors on target cells to activate distinct downstream signaling pathways. The beta subunit of CG is encoded by six highly homologous genes which are arranged in tandem and inverted pairs on chromosome 19. Abnormalities in the CG beta subunit can cause ectopic pregnancy.

P1714 | Human Chorionic Gonadotropin, β Subunit DataSheet

Biomolecule/Target :

Synonyms: Choriogonadotropin subunit beta; chorionic gonadotropin chain beta; CG-Beta; HCGB; CGB; HCG

Alternates names:

Taglines: Unique beta subunit of human chorionic gonadotropin; native protein isolated from human urine

NCBI Gene ID #: 93659

NCBI Gene Symbol:

Gene Source: Human

Accession #: P0DN86

Recombinant: False

Source: Human urine

Purity by SDS-PAGE: ≥ 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method): Activity verified by Accubind ELISA

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 22 kDa

Concentration:

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute using neutral pH buffer of choice. Avoid extreme high and low pH.

Amino acid sequence: Full length native protein (beta subunit only)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans