Human FGF19 protein | PRP100298

Human FGF19 protein | PRP100298 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cytokines

Product Type: Cytokines

Sequence: Amino acid sequence derived from mature form of human FGF19 (O95750) (Phe27-Lys216) was expressed, with a N-terminal Met.

Activity: N/A

protein Lenght: The recombinant human FGF19 consists of 191 amino acids and predicts a molecular mass of 21.4 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.

Preparation: E. coli

Purity: > 97 % as determined by SDS-PAGE

Formulation: Lyophilized from sterile 15% gly, 50mM Tris, 2mM EDTA

Kit Component: N/A

Features & Benefits : N/A

Molecular Weight: 21.4 kDa

Usage Note: Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human FGF19 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage Conditions: Lyophilized Human FGF19 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.75% HSA or BSA) . Please prevent freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature.

Background: FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes.

Alternative Names: FGF19; Fibroblast growth factor 19; FGF19

Search Names: FGF19; Fibroblast growth factor 19; FGF19

Tag: FGF19