Human Fibrinogen (PAD4 Citrullinated) | P1719

Fibrinogen is a glycoprotein complex composed of three different polypeptides (α, β, γ) that is cleaved by thrombin to form an insoluble fibrin matrix that acts as a plasma clotting factor. Cleavage products of fibrinogen and fibrin regulate cell adhesion and activate chemotaxis. Chronic inflammation can induce protein arginine deiminases (such as PAD2 and PAD4) to citrullinate fibrinogen, which has been associated with auto-antibodies in rheumatoid arthritis.

P1719 | Human Fibrinogen (PAD4 Citrullinated) DataSheet

Biomolecule/Target :

Synonyms: Fib2; FGA; HEL-S-78p; FGB; FGG

Alternates names:

Taglines: A critical factor in blood clotting, inflammation, and rheumatoid arthritis

NCBI Gene ID #: α - 2243; β - 2244; γ - 2266

NCBI Gene Symbol:

Gene Source: Human

Accession #: α - P02671; β - P02675; γ - P02679

Recombinant: False

Source: Human plasma

Purity by SDS-PAGE: ≥ 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method):

Biological activity:

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Binding Capacity:

Unit Definition:

Molecular Weight: α - 2 isoforms at 95 kDa and 69.8 kDa; β - 55.9 kDa; γ - 51.5 kDa

Concentration:

Appearance: Liquid protein

Physical form description:

Reconstitution Instructions:

Amino acid sequence: Purified from human plasma that tested negative for HBsAg and for antibodies to HIV and HCV; citrullinated with human recombinant PAD2

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans