human IgG antibody [APR33695G]

human IgG antibody [APR33695G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Polyclonal

Species Reactivity: H

Specificity: N/A

Cellular Localisation: Secreted. Cell membrane

Molecular Weight: 36106

Clone: Polyclonal

Gene Name: IGHG1 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.11}

Gene ID: N/A

Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:500 IHC-P--1:500-1:1000

Synonyms: N/A