Human Tau-383 | P1621

Tau is a neuronal microtubule-associated protein. It stabilizes microtubules in axons. Tau protein become hyperphosphorylated and forms insoluble aggregates called neurofibrillary tangles in Alzheimer's disease. The accumulation of abnormal tau aggregates causes cytoxicity, which is described as a gain-of-toxic function model. Tau gene undergoes alternative splicing, giving rise to six different isoforms. Tau-383 isoform contains exon 10 and lacks exons 2 and 3.

P1621 | Human Tau-383 DataSheet

Biomolecule/Target :

Synonyms: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; mAP; MAPTL; MTBT1; Tau 0N4R; tau isoform 3; ht24; 4RS tau; Isoform Tau-D

Alternates names: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; mAP; MAPTL; MTBT1; Tau 0N4R; tau isoform 3; ht24; 4RS tau; Isoform Tau-D

Taglines: A tau isoform

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #: P10636; NP_058518

Recombinant: TRUE

Source: E.coli

Purity by SDS-PAGE: ≥ 85% by SDS-PAGE

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Unit Definition:

Molecular Weight: 42.1 kDa

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Appearance: Liquid

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Reconstitution Instructions:

Amino acid sequence: The target protein is expressed with the sequence (aa 1-383) of human tau-383 fused to His-tag at the N-terminus.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans