HUWE1 Polyclonal Antibody | E-AB-19540

HUWE1 Polyclonal Antibody | E-AB-19540 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ARF binding protein 1, ARF BP1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, E3 ubiquitin protein ligase HUWE1, E3 ubiquitin-protein ligase HUWE1, HECT, HECT domain protein LASU1, HECT UBA and WWE domain containing protein 1, HectH9, Homologous to E6AP carboxyl terminus homologous protein 9, Huwe1, HUWE1, Ib772, Large structure of UREB1, LASU1, Mcl 1 ubiquitin ligase E3, Mcl-1 ubiquitin ligase E3, Mule, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE-B1, URE-binding protein 1, UREB1

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology

Background: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human HUWE1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:10-1:50, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A