I-BET762 | 2628

I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell proliferation and suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation.

I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell proliferation and suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation.

2628 | I-BET762 DataSheet

Alternate Name/Synonyms: (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide; GSK525762

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1260907-17-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₂ClN₅O₂

Molecular Weight: 423.9

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent bromodomain inhibitor

MDL Number: N/A

PubChem CID: 46943432

SMILES: CCNC(=O)CC1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C

InChi: nChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1

InChi Key: AAAQFGUYHFJNHI-SFHVURJKSA-N