I-BRD9 | B2857

I-BRD9 is an inhibitor and chemical probe for BRD9 bromodomain. BRD9 (bromodomain-containing protein 9) is a part of the chromatin remodeling SWI/SNF BAF complex. Bromodomain "reader" modules recognize the acetylation of histone lysine residues. I-BRD9 has a pIC₅₀ of 7.3 and displays >700-fold selectivity over the BET (bromodomains and extra-terminal) family and >70-fold against a panel of 34 bromodomains.

I-BRD9 is an inhibitor and chemical probe for BRD9 bromodomain. BRD9 (bromodomain-containing protein 9) is a part of the chromatin remodeling SWI/SNF BAF complex. Bromodomain "reader" modules recognize the acetylation of histone lysine residues. I-BRD9 has a pIC₅₀ of 7.3 and displays >700-fold selectivity over the BET (bromodomains and extra-terminal) family and >70-fold against a panel of 34 bromodomains.

B2857 | I-BRD9 DataSheet

Alternate Name/Synonyms: N'-(1,1-dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide; N'-[1,1-Bis(Oxidanylidene)thian-4-Yl]-5-Ethyl-4-Oxidanylidene-7-[3-(Trifluoromethyl)phenyl]thieno[3,2-C]pyridine-2-Carboximidamide; N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide; 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-thieno[3,2-c]pyridine-2-carboximidamide; N-(1,1-dioxo-1lambda6-thian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]-4H,5H-thieno[3,2-c]pyridine-2-carboximidamide; GSK602

Appearance: A crystalline solid

Formulation:

CAS Number: 1714146-59-4

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₂₂F₃N₃O₃S₂

Molecular Weight: 497.55

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~30 mg/ml in DMF in 0, ~25 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of BRD9 bromodomain

MDL Number: MFCD28952791

PubChem CID: 91668541

SMILES: CCN1C=C(C2=C(C1=O)C=C(S2)C(=NC3CCS(=O)(=O)CC3)N)C4=CC(=CC=C4)C(F)(F)F

InChi: InChI=1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27)

InChi Key: WRUWGLUCNBMGPS-UHFFFAOYSA-N