Iberdomide | B2284

Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.

Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.

B2284 | Iberdomide DataSheet

Alternate Name/Synonyms: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; CC-220

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1323403-33-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₇N₃O₅

Molecular Weight: 449.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A celebron modulator

MDL Number: N/A

PubChem CID: 67335295

SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5

InChi: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1

InChi Key: IXZOHGPZAQLIBH-NRFANRHFSA-N