Description
Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.
Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.
Alternate Name/Synonyms: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; CC-220
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1323403-33-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₇N₃O₅
Molecular Weight: 449.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A celebron modulator
MDL Number: N/A
PubChem CID: 67335295
SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5
InChi: InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
InChi Key: IXZOHGPZAQLIBH-NRFANRHFSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |