IC87114 | 1661

Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC₅₀ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 µM.

IC87114 is a potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC₅₀ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 µM.

1661 | IC87114 DataSheet

Alternate Name/Synonyms: 2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 371242-69-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₉N₇O

Molecular Weight: 397.43

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PI3 Kinase inhibitor

MDL Number: MFCD09970845

PubChem CID: 9908783

SMILES: CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C4N=CN=C5N

InChi: InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22 (29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3, (H2,23,24,25)

InChi Key: GNWHRHGTIBRNSM-UHFFFAOYSA-N