ICOSLG /B7-H2 /CD275, mouse recombinant | P1106

Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

P1106 | ICOSLG /B7-H2 /CD275 mouse recombinant DataSheet

Biomolecule/Target: Icoslg

Synonyms: B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1

Alternates names: FK506 binding protein 6, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase

Taglines: Ligand for the T-cell-specific cell surface receptor ICOS

NCBI Gene ID #: 2288

NCBI Gene Symbol: FKBP4

Gene Source: Human

Accession #: Q02790

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.06 EU/g

Activity (Specifications/test method): N/A

Biological activity: Specific activity is > 300 nmoles/min/mg.

Results:

Binding Capacity: Immobilized human ICOS at 1g/ml (100l/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0g/ml.

Unit Definition: N/A

Molecular Weight: 53.9 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2 m-filtered solution in PBS

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA